Very important terms of coordination chemistry 2. Essential Trace Elements  Iron  Iron is one of the metals found in greatest abundance in biological systems in the form of porphyrin complexes such as haemoglobin & myoglobin. Hard ions: Na+, K, Mg2+, Ca 5. Bio-inorganic Chemistry Bioinorganic Chemistry is devoted to all aspects of “inorganic elements” (such as transition metals) as being vital for the growth and metabolism of living systems. 2. Cobalamines 6. Metals in Photosynthesis 7. Fixation of nitrogen Coordination for uptake, transport and storage (Fe) 4. Table 3.1 Approximate Elemental Composition of a Typical 70kg Human Bulk elements and mineral ions Phosphorus Potassium Chlorine Sulfur Sodium Magnesium Barium Molybdenum Boron Arsenic Cobalt Chromium Nickel Selenium Lithium Vanadium 680 g 250 g 21 mg 14 mg 14 mg —3 mg Oxygen Carbon Hydrogen Nitrogen Calcium 12.6 kg 6.6 kg Trace and ultra-trace elements Iron Silicon Zinc Rubidium Copper Strontium Bromine Tin … Cobalamines 6.  Of total iron in the human body,70% is present in haemoglobin & about 3%in myoglobin. General aspects of bioinorganic chemistry 3. ULTRATRACE ELEMENTS Needed at less than 1 ppm or 50 ppb Includes As, B, Si, Ni, V in humans Other elements include Br, Cd , F , Pb , Li, Sn Quite toxic at any concentration much above concentrations ultra trace level For metals, coordination chemistry …  Most of the remaining iron is stored as ferritin. Based on the relative concentrations in the biological systems, the metals are divided into: Bulk metals - Na, K, Mg & Ca Trace metals - Zn, Fe, Co, Ni, Cu, Mo, V etc., which are present in … Small molecule and biomolecular interactions enable not just the intake, uptake, and transport of essential elements, but also maintenance of the optimal level of the elements (homeostasis). General aspects of bioinorganic chemistry 3. Coordination for uptake, transport and storage (Fe) 4. 1.  Ferritin is major iron storage protein in mammals but is also found in plant … Hard ions: Na +, K , Mg2+, Ca2+ 5. Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, Second Edition provides a detailed introduction to the role of inorganic elements in biology, taking a systematic element-by-element approach to the topic. Function of Zn 9. Fe in bio systems 8. The inorganic elements, especially the metals play an important role in biological systems. Essential Elements follow a Dose-response curve.